What are the Symptoms of Vein Disease? Vein disease may produce no bothersome symptoms at all. However, in cases which do become symptomatic, the following are among the most commonly observed side effects: Vein Disease Symptoms Discoloration – Veins may appear blue or purplish in color. The skin surrounding varicose veins may also become discolored. Protrusion – As veins become enlarged, they may protrude from skin, with a cord or rope-like appearance. Dry or weeping eczema Leg Ulcers Restless Legs Pain – Legs may ache, cramp, burn, throb or feel heavy. These symptoms may be worse after prolonged periods of sitting. Itching – Itching may occur in areas around one or more of the affected veins. Book an Appointment The Leg & Vein Center at Cardiovascular Institute of the South diagnoses and treats cardiovascular conditions in the legs, such as peripheral artery disease and vein disease. Our cardiologists are among the most-renowned venous disease specialists in the nation. Book an Appointment Today Leg & Vein Center Vein Disease Vein Disease Risk Factors Diagnosing & Treating Vein Disease CIS Leg & Vein Centers operate in the following areas: Baton Rouge 8401 Picardy AvenueBaton Rouge, LA 70809 Phone (225) 308-0247 Toll-Free (225) 308-0247 Fax (225) 308-0249 Gray 191 Innovation Court, Suite AGray, LA 70359 Phone (985) 303-4100 Toll-Free (877) 846-0132 Fax (985) 303-4101 Houma 225 Dunn StreetHouma, LA 70360 Phone (985) 876-0300 Toll-Free (800) 445-9676 Fax (985) 876-4605 Jennings 422 Kade Drive, Suite 1Jennings, LA 70546 Phone (337) 388-6200 Toll-Free (844) 625-0436 Fax (337) 388-6201 Lafayette on Heymann 441 Heymann BoulevardLafayette, LA 70503 Phone (337) 289-8429 Toll-Free (877) 588-8429 Fax (337) 289-8431 Lafayette on Ambassador 2730 Ambassador Caffery ParkwayLafayette, LA 70506 Phone (337) 988-1585 Toll-Free (800) 582-2435 Fax (337) 981-4694 Meridian 4909 Great River DriveMeridian, MS 39305 Phone (601) 282-8980 Toll-Free (844) 643-6200 Fax 601-693-6561 New Iberia 500 North Lewis Street, Suite 100New Iberia, LA 70563 Phone (337) 367-5200 Toll-Free (800) 555-7604 Fax (337) 369-3074 Opelousas 1233 Wayne Gilmore Circle, Suite 450Opelousas, LA 70570 Phone (337) 942-3006 Toll-Free (800) 553-2394 Fax (337) 942-7744 Thibodaux 1320 Martin Luther King DriveThibodaux, LA 70301 Phone (985) 446-2021 Toll-Free (800) 340-7030 Fax (985) 493-3818 Westbank 1901 Manhattan Blvd, Building A, Suite 200Harvey, LA 70058 Phone (504) 354-5252 Toll-Free (833) 620-5252 Fax (504) 354-5253 Zachary 6550 Main Street, Suite 1000Zachary, LA 70791 Phone (225) 654-1559 Toll-Free (877) 654-3965 Fax (225) 654-6212